Only two or three months after the death of his uncle, did Allah’s Messenger (صلى الله عليه و سلم) experience another great personal loss. The Mother of believers, his wife Khadijah (رضى الله عنها) passed away in Ramadan of the tenth year of his Prophethood, when she was sixty-five years old, and he was fifty. [Talqih Fuhum Ahlil-Athar p.7] Khadija (رضى الله عنها) was in fact a blessing of Allah for the Prophet (صلى الله عليه و سلم). She, for twenty-five years, shared with him the toils and trials of life, especially in the first ten years of his Prophethood. He deeply mourned over her death, and once he replied in an honest burst of tender emotions. 

"امنت بى حين كفر بى الناس و صدقتنى حين كذبنى الناس و اشركتنى فى مالها حين حرمنى الناس و رزقنى الله ولدها و حرم ولد غيرها"

"She believed in me while the people disbelieved in me. And she trusted in me while the people belied me. And she helped and comforted me, in person and wealth, when the people would not. Allah provided me with children by her, and He did not with others." [Musnad Imam Ahmad 6/118]

Abu Hurairah (رضى الله عنه) reported that Jibreel (عليه السلام) came to Allah’s Messenger (صلى الله عليه و سلم) and said: “Allah’s Messenger, lo, Khadijah is coming to you with a vessel of seasoned food or drink. When she comes to you, offer her greetings from her Lord, and give her glad tidings of a palace of jewels in Paradise where there is no noise and no toil.” [Sahih Al-Bukhari 1/539]

"The Sealed Nectar," page 151.